Chelsea Handler has defended best friend Jennifer Aniston again against 'crazy' claims that she spends her time thinking about the Angelina Jolie, Brad Pitt divorce.

The US comedian and TV host told You magazine: 'I don't think Jen cares about what's going on and it's crazy that people think she does.'

'As if she's sitting around caring about [Angelina Jolie]. I know I don't.'

The star previously told another publication last year that it was 'ridiculous' that anyone would think Aniston would be concerned with ex-husband Pitt's separation from Jolie.

She then launched into a stinging opinion of the situation, in a trailer for her Netflix talk show, saying: 'There are reports that part of the problem was Brad was allegedly drinking and smoking too much weed.

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'I wonder why he needed to self-medicate. Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages?'

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Handler also spoke to You about the best and worst celebrities she's interviewed for both her Netflix series and her E! show Chelsea Lately, and how she considers herself an honorary Brit.

'Russell Brand was a huge pain in the ass but I'd love to interview Hugh Laurie,' she told the magazine. 'He'd be great. The British have a very dry sense of humour, which I love. I always feel like I'm British anyway.'

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She added that Tom Hiddleston was 'very sweet' but 'very square' when they met, and hopes to visit the set of Netflix's award-winning series The Crown.

'I like Brits - I interviewed Tom Hiddleston and he was very sweet and very square,' she reflected.

'We're going to England soon, so hopefully we'll do something on the set of The Crown - it would be very exciting to interview Claire Foy.'

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Naomi Gordon

Naomi Gordon is news writer mainly covering entertainment news with a focus on celebrity interviews and television.