At this stage, only one thing about the house's future is certain, and that's that it won't be the same without the ultimate flamboyant fashion designer at its helm.
His public persona is almost as notorious as his ultra-wearable designs. Aged 50, many consider him to be at the top of his game - and looking better than ever. Fun-loving and free spirited, this is a designer who loves to bathe in the limelight, whether soaking up the praise post-show on the runway, or flaunting his gym-honed physique.
Click through the gallery to see his most iconic looks to date. Au revoir, Marc.
Marc Jacobs at the Fashion Media Awards, New York, September 2013.
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Marc Jacobs at the Costume Institute Gala Benefit celebrating the Punk: Chaos To Couture exhibition New York, May 2013.
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Marc Jacobs at the 'Disconnect' film screening and dinner party, New York, March 2013.
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Mark Jacobs walks down the runway at the end of the Louis Vuitton show Autumn Winter 2013 wearing printed pyjamas, March 2013.
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Marc Jacobs wearing a tartan shirt and trousers closes his Autumn Winter 2013 show, 2013.
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Marc Jacobs and Diaz attend the launch party announcing Marc Jacobs as the Creative Director for Diet Coke, March 2013.
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Marc Jacobs and Kate celebrate Kate Moss' book launch at his party, November 2012.
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Marc Jacobs at the CFDA Fashion Awards wears a classic tux, June 2012.
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Marc Jacobs wears a skirt out and about in Soho, March 2012.
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Marc Jacobs and Anna Wintour at the Metropolitan Museum's Costume Institute The Model as Muse: Embodying Fashion event, May 2009.
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Marc Jacobs is dressed as a Camel Toe for an Arabian Nights themed holiday party, December 2007.
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Marc Jacobs and Victoria Beckham pose for the cameras at Olympus Fashion Week Spring, September 2006.
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Marc Jacobs and Robert Duffy at his holiday party, December 2006.
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Marc Jacobs and Naomi Campbell at his Christmas party, December 2005.
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Marc Jacobs and Sofia Coppola attend the Dangerous Liasons: The Art of Seduction exhibit during The Metropolitan Museums Costume Institute Benefit Gala, April 2004.
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Marc Jacobs and Naomi Campbell arrive at the Tommy Hilfiger Rock Style Exhibit, December 1999.
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Marc Jacobs and Kate Moss Vuitton store in New York, January 1996.
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Marc Jacobs at the Club M.K. in New York City, April 1990.